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Threonine

THREE-oh-neen

Macronutrient

An amino acid that keeps the protective lining of your gut healthy, supports your immune system, and helps prevent fat buildup in your liver.

Threonine is the main ingredient in the mucus coating that protects your gut — like the non-stick coating on a frying pan, it prevents your intestinal wall from being damaged by food and acid.

What it does in the body

  • Intestinal mucin glycoprotein synthesis (gut barrier)
  • Collagen and elastin synthesis
  • Immune function (antibody production — IgG, IgA)
  • Lipotropic function (prevents fatty liver)
  • Glycoprotein and cell signaling molecule synthesis

How much you need (Daily Value)

GroupRecommendedSource
Adult male15mg/kg/day (~1.05g for 70kg)WHO/FAO/UNU
Adult female15mg/kg/day (~0.9g for 60kg)WHO/FAO/UNU
Pregnancy19mg/kg/dayWHO
Children17-31mg/kg/day depending on ageWHO
Older adults15mg/kg/day; higher in gut diseaseWHO

Richest food sources

FoodAmountWhere
Beef (lean, cooked)1.2g per 100gglobal
Chicken breast (cooked)1.1g per 100gglobal
Cottage cheese0.6g per 100geurope
Lentils (cooked)0.3g per 100gsouth-asia
Salmon (cooked)1.0g per 100gglobal
Eggs (whole)0.6g per 100gglobal
Tofu (firm)0.5g per 100geast-asia
Watercress0.1g per 100gglobal

If you don't get enough

Mild: Mild digestive discomfort, reduced mucus production, minor immune impairment

Moderate: Compromised gut barrier, increased susceptibility to infections, fatty liver development, poor wound healing

Severe: Severe gut barrier breakdown, malabsorption, hepatic steatosis, neurological irritability, edema

Time to onset: Gut mucin changes within 1-2 weeks; systemic effects within 4-8 weeks

Too much

Upper limit: No established UL; doses up to 4g/day appear safe in studies

Very high doses may cause nausea, headache, and GI distress. Minimal toxicity risk compared to other amino acids

How well you absorb it

85-95% from animal proteins; 70-85% from plant sources. Note: 40-60% undergoes first-pass gut metabolism

Helped by: Vitamin B6 (cofactor for threonine dehydratase), Adequate glycine availability, Normal gut health

Hindered by: Gut inflammation (paradoxically increases need while potentially reducing absorption), Antinutrients in raw legumes

Cooking & storage

Moderately heat-stable. Standard cooking methods preserve threonine well. Prolonged boiling can leach threonine into cooking water — using broth-based cooking retains it.

Did you know. Threonine is the second most limiting amino acid in rice-based diets (after lysine), affecting populations across Southeast Asia and parts of Sub-Saharan Africa dependent on cereal staples.

Educational reference only. Nutrient needs vary with age, sex, health, and medication. Not medical or dietary advice. See our full disclaimer.
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Evidence grades: A — meta-analyses / large trials; B — cohort studies & guidelines; C — expert consensus. Links open in a new tab.

AProtein and Amino Acid Requirements in Human Nutrition — WHO/FAO/UNU, 2007
BThreonine Metabolism and Gut Health — British Journal of Nutrition, 2017