koh-LES-ter-all
Macronutrient
A waxy substance your body needs to make hormones, vitamin D, and bile for digestion. Your liver makes most of what you need — eating cholesterol in food matters less than we once thought, but still matters for some people.
| Group | Recommended | Source |
|---|---|---|
| Adult male | No RDA or UL; body produces ~800-1000mg/day. Prudent limit <300mg/day dietary | DGA 2020/AHA |
| Adult female | Same as male | DGA 2020/AHA |
| Pregnancy | Cholesterol is essential for fetal development; no restriction needed unless hyperlipidemic | ACOG |
| Children | No specific limit; focus on overall healthy eating pattern | AHA |
| Older adults | Focus on LDL-C levels and CVD risk rather than dietary cholesterol per se | ACC/AHA |
| Food | Amount | Where |
|---|---|---|
| Egg yolk (1 large egg) | 186mg per egg | global |
| Beef liver (cooked) | 396mg per 100g | global |
| Shrimp (cooked) | 195mg per 100g | global |
| Butter | 215mg per 100g | global |
| Cheese (cheddar) | 105mg per 100g | europe |
| Sardines (canned) | 142mg per 100g | mediterranean |
| Chicken breast (cooked, with skin) | 85mg per 100g | global |
| Squid/calamari | 233mg per 100g | mediterranean |
Mild: Extremely rare given endogenous synthesis; theoretical: reduced hormone production
Moderate: Smith-Lemli-Opitz syndrome (cholesterol synthesis defect): growth failure, intellectual disability, multiple organ anomalies
Severe: Lethal if complete absence (incompatible with life; not seen as dietary deficiency)
Time to onset: Not applicable for dietary deficiency — body maintains cholesterol homeostasis
Upper limit: No established UL (2020 DGA); prudent to limit <300mg/day in hyper-responders. AHA recommends limiting but sets no specific cap
Elevated LDL cholesterol in susceptible individuals, accelerated atherosclerosis, increased cardiovascular disease risk. Familial hypercholesterolemia causes LDL >300 mg/dL
40-60% of dietary cholesterol absorbed; highly variable between individuals. Regulated by NPC1L1 transporter (target of ezetimibe)
Helped by: Bile salts (essential for micellar solubilization), Saturated fat co-ingestion
Hindered by: Plant sterols and stanols (compete for absorption; 2g/day reduces LDL by ~10%), Ezetimibe (blocks NPC1L1), Fiber (binds bile acids)
Cholesterol in foods is heat-stable and not significantly affected by normal cooking methods. However, cholesterol can form cholesterol oxidation products (COPs) at very high temperatures, which are more atherogenic than native cholesterol. Avoid charring cholesterol-rich foods.
Evidence grades: A — meta-analyses / large trials; B — cohort studies & guidelines; C — expert consensus. Links open in a new tab.