POL-ee-un-SACH-uh-ray-ted fat
Macronutrient
Essential fats with multiple bends in their chain — your body absolutely cannot make them, so you must eat them. They include omega-3 (anti-inflammatory) and omega-6 (pro-inflammatory in excess) fats.
| Group | Recommended | Source |
|---|---|---|
| Adult male | 6-11% of total calories (~13-24g on 2000 kcal diet); omega-6:omega-3 ratio ideally 4:1 or lower | IOM/WHO |
| Adult female | 6-11% of total calories | IOM/WHO |
| Pregnancy | At least 200mg DHA/day in addition to general PUFA needs | WHO/FAO |
| Children | Essential for brain development; 5-10% of calories | IOM |
| Older adults | Same as adults; emphasize omega-3 for anti-inflammatory and neuroprotective effects | IOM/AHA |
| Food | Amount | Where |
|---|---|---|
| Flaxseed oil | 68g per 100g (53g ALA) | global |
| Walnuts | 47g per 100g | global |
| Sunflower oil | 66g per 100g (mostly omega-6) | global |
| Salmon (wild, cooked) | 2.5g omega-3 per 100g | global |
| Soybean oil | 58g per 100g | east-asia |
| Chia seeds | 31g per 100g (mostly ALA) | mesoamerica |
| Corn oil | 55g per 100g (mostly omega-6) | north-america |
| Hemp seeds | 38g per 100g (balanced omega-6:omega-3) | global |
Mild: Dry skin, mild eczema, poor wound healing
Moderate: Dermatitis, hair loss, impaired immune function, poor growth in children, visual impairment
Severe: Severe growth retardation, reproductive failure, neurological deficits, scaly dermatitis (essential fatty acid deficiency syndrome)
Time to onset: Skin changes within 2-4 weeks of fat-free parenteral nutrition; systemic deficiency within 4-8 weeks
Upper limit: No UL established; total PUFAs recommended at 6-11% of calories. Excessive omega-6 may promote inflammation. High PUFA intake requires increased vitamin E
Lipid peroxidation, increased oxidative stress, potential immune suppression at very high doses. Bleeding risk with very high omega-3 intake
95-100% absorbed via standard fat digestion pathways
Helped by: Vitamin E (protects PUFAs from peroxidation), Bile salts, Antioxidant-rich foods consumed alongside
Hindered by: Oxidation during cooking/storage (destroys PUFA integrity), Rancidity, Orlistat
PUFAs are the most vulnerable fats to heat damage and oxidation. Seed oils high in PUFAs (soybean, corn, sunflower) should not be used for high-heat cooking or deep frying. Use for dressings or low-heat cooking. Store in dark, cool conditions.
Evidence grades: A — meta-analyses / large trials; B — cohort studies & guidelines; C — expert consensus. Links open in a new tab.