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Selenium

seh-LEE-nee-um

Mineral

A powerful antioxidant mineral that protects your cells, supports thyroid function, and helps your immune system fight infections.

Selenium in your body is like the security system in a building — its selenoproteins constantly patrol for and neutralize toxic oxidative threats that could damage your DNA and cells.

What it does in the body

  • Antioxidant defense (glutathione peroxidase family)
  • Thyroid hormone metabolism (T4 to T3 conversion)
  • Immune function (enhanced NK cell activity, antibody production)
  • DNA repair and cancer protection
  • Male fertility (selenoprotein in sperm capsule)

How much you need (Daily Value)

GroupRecommendedSource
Adult male55 mcgNIH/IOM
Adult female55 mcgNIH/IOM
Pregnancy60 mcgWHO/IOM
Children20 mcg (1-3y), 30 mcg (4-8y), 40-55 mcg (9-18y)NIH/IOM
Older adults55 mcgNIH/IOM

Richest food sources

FoodAmountWhere
Brazil nuts1917 mcg per 100g (1 nut ≈ 70-90 mcg)South America
Yellowfin tuna92 mcg per 100gglobal oceans
Halibut47 mcg per 100gNorth Pacific/Atlantic
Sardines53 mcg per 100gMediterranean
Chicken breast27 mcg per 100gglobal
Eggs31 mcg per 100gglobal
Sunflower seeds53 mcg per 100gAmericas/Europe
Brown rice (cooked)10 mcg per 100gglobal

If you don't get enough

Mild: Subtle immune impairment, fatigue, muscle weakness, increased susceptibility to viral mutation (Coxsackievirus can become virulent in selenium-deficient hosts)

Moderate: Thyroid dysfunction (impaired T4 to T3 conversion), nail and hair changes, increased oxidative stress, male infertility

Severe: Keshan disease (fatal cardiomyopathy), Kashin-Beck disease (osteoarthropathy), myxedematous cretinism (with concurrent iodine deficiency)

Time to onset: Months to years for dietary deficiency. Keshan disease onset accelerated by concurrent viral infection.

Too much

Upper limit: 400 mcg/day (adults)

Selenosis: garlic breath odor, hair loss, nail brittleness/loss, nausea, diarrhea, peripheral neuropathy, skin rash. Acute toxicity can cause pulmonary edema and cardiac failure.

How well you absorb it

>80% for organic forms (selenomethionine, selenocysteine); 50-60% for inorganic forms (selenite, selenate)

Helped by: Protein (amino acid context improves absorption), Vitamins A, C, E (synergistic antioxidant network)

Hindered by: Heavy metals (mercury, cadmium, arsenic), High sulfur intake, Excessive selenium itself (auto-inhibition at high doses)

Cooking & storage

Selenium is relatively heat-stable but can be lost through boiling water (leaching). Selenium content of plant foods varies dramatically based on soil selenium content — the same food can vary 100-fold depending on growing region.

Did you know. An estimated 500 million to 1 billion people worldwide live in selenium-deficient regions, including parts of China, Russia, Africa, and New Zealand. Soil selenium depletion is projected to worsen with climate change.

Educational reference only. Nutrient needs vary with age, sex, health, and medication. Not medical or dietary advice. See our full disclaimer.
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Evidence grades: A — meta-analyses / large trials; B — cohort studies & guidelines; C — expert consensus. Links open in a new tab.

ASelenium Fact Sheet for Health Professionals — NIH Office of Dietary Supplements, 2024
AVitamin and Mineral Requirements in Human Nutrition — WHO/FAO, 2004
ASelenium and Human Health — Lancet, 2012