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Vitamin D (Cholecalciferol)

VIT-uh-min DEE / koh-leh-kal-SIF-er-all

Vitamin

The 'sunshine vitamin' that keeps your bones strong and your immune system functioning properly.

Vitamin D is like a construction foreman for your bones — it directs calcium and phosphorus to where they need to go. Without the foreman, the building materials just pile up uselessly.

What it does in the body

  • Calcium and phosphorus absorption from the intestine
  • Bone mineralization and remodeling via osteoblast regulation
  • Immune system modulation (innate and adaptive immunity)
  • Insulin secretion regulation and glucose metabolism
  • Muscle function and neuromuscular coordination

How much you need (Daily Value)

GroupRecommendedSource
Adult male15 mcg (600 IU)NIH/IOM
Adult female15 mcg (600 IU)NIH/IOM
Pregnancy15 mcg (600 IU)WHO/IOM
Children15 mcg (600 IU) ages 1-18WHO
Older adults20 mcg (800 IU) age 71+NIH/IOM

Richest food sources

FoodAmountWhere
Cod liver oil250 mcg (10,000 IU) per tablespoonNorthern Europe
Salmon (wild-caught)14.2 mcg (568 IU) per 100gglobal
Sardines (canned)4.8 mcg (193 IU) per 100gMediterranean/global
Fortified milk2.5 mcg (100 IU) per 240mlAmericas/Europe
Egg yolk2.0 mcg (82 IU) per yolkglobal
UV-exposed mushrooms (shiitake)18 mcg (720 IU) per 100gEast Asia
Fortified orange juice2.5 mcg (100 IU) per 240mlAmericas
Herring (pickled)17 mcg (680 IU) per 100gNorthern Europe/Scandinavia

If you don't get enough

Mild: Fatigue, muscle weakness, bone aches, increased susceptibility to infections

Moderate: Osteopenia, secondary hyperparathyroidism, proximal muscle weakness, increased fracture risk

Severe: Rickets in children (bowed legs, rachitic rosary), osteomalacia in adults (bone softening), severe immunodeficiency

Time to onset: Serum levels decline over weeks without sun/dietary intake; clinical rickets develops over months in growing children

Too much

Upper limit: 100 mcg (4000 IU)/day for adults; toxicity typically at >10,000 IU/day chronically

Hypercalcemia causing nausea, vomiting, confusion, polyuria, nephrocalcinosis, cardiac arrhythmias. Cannot occur from sun exposure alone.

How well you absorb it

55-99% of oral vitamin D absorbed in the small intestine with fat

Helped by: Dietary fat (take supplements with largest meal), UVB exposure (10-30 min midday sun), Magnesium (cofactor for vitamin D metabolism)

Hindered by: Obesity (sequestration in adipose tissue), Dark skin pigmentation (higher latitudes), Sunscreen SPF 30+ (blocks 95% UVB), Fat malabsorption disorders

Cooking & storage

Vitamin D is relatively heat-stable. Baking and frying retain 80-100% of vitamin D content. Boiling fish retains most vitamin D in the liquid.

Did you know. An estimated 1 billion people worldwide have vitamin D deficiency or insufficiency, making it the most prevalent nutritional deficiency globally. Rickets is re-emerging in developed countries.

Educational reference only. Nutrient needs vary with age, sex, health, and medication. Not medical or dietary advice. See our full disclaimer.
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Evidence grades: A — meta-analyses / large trials; B — cohort studies & guidelines; C — expert consensus. Links open in a new tab.

AVitamin D Fact Sheet for Health Professionals — NIH Office of Dietary Supplements, 2023
AVitamin D supplementation guidelines: current evidence and future directions — The Lancet Diabetes & Endocrinology, 2022
AEvaluation, Treatment, and Prevention of Vitamin D Deficiency Clinical Practice Guideline — Endocrine Society, 2024